A genetic interaction map of cell cycle regulators
نویسندگان
چکیده
منابع مشابه
A genetic interaction map of cell cycle regulators
Cell-based RNA interference (RNAi) is a powerful approach to screen for modulators of many cellular processes. However, resulting candidate gene lists from cell-based assays comprise diverse effectors, both direct and indirect, and further dissecting their functions can be challenging. Here we screened a genome-wide RNAi library for modulators of mitosis and cytokinesis inDrosophilaS2 cells. Th...
متن کاملAltered expression of cell cycle regulators in adult T-cell leukemia/lymphoma patients
Abstract Background: Adult T-cell leukemia/lymphoma (ATLL) is caused by human T-cell lymphotropic virus type-1 (HTLV-1). HTLV-1 oncogenes can induce malignancy through controlled gene expression of cell cycle checkpoints in the host cell. HTLV-I genes play a pivotal role in overriding cell cycle checkpoints and deregulate cellular division. In this study, we aimed to determine and comp...
متن کاملCharting the genetic interaction map of a cell.
Genome sequencing projects have revealed a massive catalog of genes and astounding genetic diversity in a variety of organisms. We are now faced with the formidable challenge of assigning functions to thousands of genes, and how to use this information to understand how genes interact and coordinate cell function. Studies indicate that the majority of eukaryotic genes are dispensable, highlight...
متن کاملSnapShot: Cell-Cycle Regulators I
function Phase S. cerevisiae (Budding Yeast) S. pombe (fission Yeast) D. melanogaster (fruit fly)
متن کاملSnapShot: Cell-Cycle Regulators II
function S. cerevisiae (Budding Yeast) S. pombe (fission Yeast) D. melanogaster (fruit fly) X. laevis (clawed Toad) H. sapiens (Human) Cdk-inhibitory kinases Phosphorylate Cdk in active site, blocking activity swe1 Wee1, Mik1 Dwee1, Dmyt1 Wee1, Myt1 Wee1, Myt1 Cdk-activating phosphatases Dephosphorylate inhibitory phosphorylation of Cdk subunit
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Molecular Biology of the Cell
سال: 2016
ISSN: 1059-1524,1939-4586
DOI: 10.1091/mbc.e15-07-0467